PRKCB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The PRKCB polyclonal antibody (Cat # PAB4533) is used in Western blot to detect PRKCB beta2 in mouse brain tissue lysate .
Western Blot (Cell lysate)
The PRKCB polyclonal antibody (Cat # PAB4533) is used in Western blot to detect PRKCB beta2 in Jurkat cell lysate .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with PRKCB polyclonal antibody (Cat # PAB4533) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PRKCB.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PRKCB.
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The PRKCB polyclonal antibody (Cat # PAB4533) is used in Western blot to detect PRKCB beta2 in mouse brain tissue lysate .Western Blot (Cell lysate)
The PRKCB polyclonal antibody (Cat # PAB4533) is used in Western blot to detect PRKCB beta2 in Jurkat cell lysate .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with PRKCB polyclonal antibody (Cat # PAB4533) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated .Enzyme-linked Immunoabsorbent Assay
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Gene Info — PRKCB
Entrez GeneID
5579Protein Accession#
NP_997700;P05127Gene Name
PRKCB
Gene Alias
MGC41878, PKC-beta, PKCB, PRKCB1, PRKCB2
Gene Description
protein kinase C, beta
Omim ID
176970Gene Ontology
HyperlinkGene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
protein kinase C, beta 1 polypeptide
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Interactome
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Pathway
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Publication Reference
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Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S.
PNAS 2007 Apr; 104(18):7444.
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Small-molecule synergist of the Wnt/beta-catenin signaling pathway.
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