GRK5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRK5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to 561-590 amino acids at C-terminus of human GRK5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with GRK5 polyclonal antibody (Cat # PAB4519) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRK5
Entrez GeneID
2869Protein Accession#
P34947Gene Name
GRK5
Gene Alias
GPRK5
Gene Description
G protein-coupled receptor kinase 5
Omim ID
600870Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
Pronin AN, Morris AJ, Surguchov A, Benovic JL.
The Journal of Biological Chemistry 2000 Aug; 275(34):26515.
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Cross-talk between orphan nuclear hormone receptor RZRalpha and peroxisome proliferator-activated receptor alpha in regulation of the peroxisomal hydratase-dehydrogenase gene.
Winrow CJ, Capone JP, Rachubinski RA.
The Journal of Biological Chemistry 1998 Nov; 273(47):31442.
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Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor.
Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M.
The Journal of Biological Chemistry 1996 Apr; 271(17):10143.
Application:WB-Tr, Rat, FRTL5 cells.
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Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
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