GRK1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GRK1 polyclonal antibody (Cat # PAB4515) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GRK1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GRK1 polyclonal antibody (Cat # PAB4515) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRK1
Entrez GeneID
6011Protein Accession#
Q15835Gene Name
GRK1
Gene Alias
GPRK1, RHOK, RK
Gene Description
G protein-coupled receptor kinase 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq
Other Designations
rhodopsin kinase
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Interactome
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Pathway
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Publication Reference
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Molecular forms of human rhodopsin kinase (GRK1).
Zhao X, Huang J, Khani SC, Palczewski K.
The Journal of Biological Chemistry 1998 Feb; 273(9):5124.
Application：IF, WB-Ti, Human, Retina.
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Molecular cloning and localization of rhodopsin kinase in the mammalian pineal.
Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K.
Visual Neuroscience 1997 Mar; 14(2):225.
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Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.
Yamamoto S, Sippel KC, Berson EL, Dryja TP.
Nature Genetics 1997 Feb; 15(2):175.
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Molecular forms of human rhodopsin kinase (GRK1).
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