SNCAIP polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The SNCAIP polyclonal antibody (Cat # PAB4495) is used in Western blot to detect SNCAIP in mouse brain lysate .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SNCAIP.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SNCAIP.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The SNCAIP polyclonal antibody (Cat # PAB4495) is used in Western blot to detect SNCAIP in mouse brain lysate .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SNCAIP
Entrez GeneID
9627Protein Accession#
NP_005451.1Gene Name
SNCAIP
Gene Alias
MGC39814, SYPH1
Gene Description
synuclein, alpha interacting protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternatively spliced transcript variants encoding different isoforms of this gene have been described, but their full-length nature has yet to be determined. [provided by RefSeq
Other Designations
synphilin|synphilin-1|synuclein alpha interacting protein
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Interactome
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Disease
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Publication Reference
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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.
Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM.
The Journal of Biological Chemistry 2004 Feb; 279(6):4625.
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Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation.
Lee G, Tanaka M, Park K, Lee SS, Kim YM, Junn E, Lee SH, Mouradian MM.
The Journal of Biological Chemistry 2003 Nov; 279(8):6834.
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Siah-1 facilitates ubiquitination and degradation of synphilin-1.
Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M.
The Journal of Biological Chemistry 2003 Dec; 278(51):51504.
Application：WB-Ti, Rat, Cerebral cortex, Hippocampus, Striatum, Cerebellum, Medulla, Spinal cord.
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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective.
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