PARK2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PARK2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PARK2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The PARK2 polyclonal antibody (Cat # PAB4479) is used in Western blot to detect PARK2 in mouse brain tissue lysate .Enzyme-linked Immunoabsorbent Assay
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Gene Info — PARK2
Entrez GeneID
5071Protein Accession#
NP_004553.1Gene Name
PARK2
Gene Alias
AR-JP, LPRS2, PDJ, PRKN
Gene Description
Parkinson disease (autosomal recessive, juvenile) 2, parkin
Gene Ontology
HyperlinkGene Summary
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq
Other Designations
E3 ubiquitin ligase|OTTHUMP00000017565|OTTHUMP00000017566|OTTHUMP00000017567|parkin|parkin 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations.
Kumru H, Santamaria J, Tolosa E, Valldeoriola F, Munoz E, Marti MJ, Iranzo A.
Annals of Neurology 2004 Oct; 56(4):599.
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Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor.
Pigullo S, De Luca A, Barone P, Marchese R, Bellone E, Colosimo A, Scaglione C, Martinelli P, Di Maria E, Pizzuti A, Abbruzzese G, Dallapiccola B, Ajmar F, Mandich P.
Parkinsonism & Related Disorders 2004 Aug; 10(6):357.
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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA.
PNAS 2004 Jul; 101(29):10810.
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Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations.
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