CSF2RB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CSF2RB.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus (V759) of human CSF2RB.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CSF2RB polyclonal antibody (Cat # PAB4461) in HL-60 cell line lysates (35 ug/lane). CSF2RB (arrow) was detected using the purified CSF2RB polyclonal antibody (Cat # PAB4461) (1 : 60 dilution).Enzyme-linked Immunoabsorbent Assay
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Gene Info — CSF2RB
Entrez GeneID
1439Protein Accession#
NP_000386;P32927Gene Name
CSF2RB
Gene Alias
CD131, CDw131, IL3RB, IL5RB
Gene Description
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq
Other Designations
GM-CSF/IL-3/IL-5 receptor common beta-chain|colony stimulating factor 2 receptor, beta|colony-stimulating factor-2 receptor, beta, low-affinity|cytokine receptor common subunit beta|interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.
Murphy JM, Ford SC, Olsen JE, Gustin SE, Jeffrey PD, Ollis DL, Young IG.
The Journal of Biological Chemistry 2004 Jun; 279(25):26500.
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Molecular assembly of the ternary granulocyte-macrophage colony-stimulating factor receptor complex.
McClure BJ, Hercus TR, Cambareri BA, Woodcock JM, Bagley CJ, Howlett GJ, Lopez AF.
Blood 2003 Feb; 101(4):1308.
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Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes.
Scibek JJ, Evergren E, Zahn S, Canziani GA, Van Ryk D, Chaiken IM.
Analytical Biochemistry 2002 Aug; 307(2):258.
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Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains.
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