GRM3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRM3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GRM3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NCI-H292 cell lysate (35 ug/lane) with GRM3 polyclonal antibody (Cat # PAB4440).Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRM3
Entrez GeneID
2913Protein Accession#
NP_000831;Q14832Gene Name
GRM3
Gene Alias
GLUR3, GPRC1C, MGLUR3, mGlu3
Gene Description
glutamate receptor, metabotropic 3
Omim ID
601115Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq
Other Designations
glutamate metabotropic receptor 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2.
Kolluri SK, Balduf C, Hofmann M, Gottlicher M.
Cancer Research 2001 Dec; 61(23):8534.
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Myristoylation of human immunodeficiency virus type 1 gag protein is required for efficient env protein transportation to the surface of cells.
Shiraishi T, Misumi S, Takama M, Takahashi I, Shoji S.
Biochemical and Biophysical Research Communications 2001 Apr; 282(5):1201.
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Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2.
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