Western blot analysis of mouse stomach tissue lysate (35 ug/lane) with GPC3 polyclonal antibody (Cat # PAB4434).
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate (35 ug/lane) with GPC3 polyclonal antibody (Cat # PAB4434).
Immunofluorecence staining of GPC3 polyclonal antibody (Cat # PAB4434) on HepG2 cells . The cells were acetone fixated . Antibody dilution of 1 : 50 . Original magnification 1 : 400 . Data and protocol courtesy of Dr . Mariana Dabeva, Department of Medicine at Albert Einstein College of Medicine .
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq