KLK7 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-231 cell lysate (35 ug/lane) with KLK7 polyclonal antibody (Cat # PAB4414).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human skin was performed with KLK7 polyclonal antibody (Cat # PAB4414) at 1:10-1:50 dilution followed by indirect peroxidase conjugation with secondary antibody and DAB staining.
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KLK7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human KLK7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemisty (1:10-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-231 cell lysate (35 ug/lane) with KLK7 polyclonal antibody (Cat # PAB4414).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin fixed and paraffin embedded human skin was performed with KLK7 polyclonal antibody (Cat # PAB4414) at 1:10-1:50 dilution followed by indirect peroxidase conjugation with secondary antibody and DAB staining. -
Gene Info — KLK7
Entrez GeneID
5650Protein Accession#
NP_644806;P49862Gene Name
KLK7
Gene Alias
PRSS6, SCCE
Gene Description
kallikrein-related peptidase 7
Omim ID
604438Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded enzyme is thought to be involved in the proteolysis of intercellular cohesive structures preceding desquamation, which is the shedding of the outermost layer of the epidermis. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq
Other Designations
kallikrein 7 (chymotryptic, stratum corneum)|protease, serine, 6|signal protein|stratum corneum chymotryptic enzyme
-
Interactome
-
Disease
- Asthma
- Birth Weight
- Dermatitis
- Eczema
- Genetic Predisposition to Disease
- Glioblastoma
- Glioma
- Leukemia
- Meningeal Neoplasms
+ View More Disease
-
Publication Reference
-
KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
Planque C, de Monte M, Guyetant S, Rollin J, Desmazes C, Panel V, Lemarie E, Courty Y.
Biochemical and Biophysical Research Communications 2005 Apr; 329(4):1260.
-
LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum.
Ishida-Yamamoto A, Deraison C, Bonnart C, Bitoun E, Robinson R, O'Brien TJ, Wakamatsu K, Ohtsubo S, Takahashi H, Hashimoto Y, Dopping-Hepenstal PJ, McGrath JA, Iizuka H, Richard G, Hovnanian A.
The Journal of Investigative Dermatology 2005 Feb; 124(2):360.
-
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R.
The Journal of Investigative Dermatology 2004 Jul; 123(1):62.
-
KLK5 and KLK7, two members of the human tissue kallikrein family, are differentially expressed in lung cancer.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com