Western blot analysis of KLK6 (arrow) using KLK6 polyclonal antibody (Cat # PAB4412). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the KLK6 gene (Lane 2).
Immunohistochemical staining of formalin fixed and paraffin embedded human breast cancer was performed with KLK6 polyclonal antibody (Cat # PAB4412) at 1:10-1:50 dilution followed by indirect peroxidase conjugation with secondary antibody and DAB staining.
Flow cytometric analysis of 293 cells (right histogram), compared to a negative control cell (left histogram), was performed with KLK6 polyclonal antibody (Cat # PAB4412) and FITC-conjugated goat-anti-rabbit secondary antibody.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq