RCAN2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RCAN2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human RCAN2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse heart tissue lysate (35 ug/lane) with RCAN2 polyclonal antibody (Cat # PAB4388).Western Blot (Cell lysate)
Western blot analysis of NCI-H460 cell lysate (35 ug/lane) with RCAN2 polyclonal antibody (Cat # PAB4388).Enzyme-linked Immunoabsorbent Assay
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Gene Info — RCAN2
Entrez GeneID
10231Protein Accession#
NP_005813;Q14206Gene Name
RCAN2
Gene Alias
CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4, hRCN2
Gene Description
regulator of calcineurin 2
Omim ID
604876Gene Ontology
HyperlinkOther Designations
Calcipressin 2 (Thyroid hormone-responsive protein ZAKI-4) (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin interacting protein 2) (MCIP2)|Down syndrome candidate region 1-like 1|Down syndrome critical region gene 1-like 1|Down synd
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Interactome
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Disease
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Publication Reference
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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.
Fuentes JJ, Genesca L, Kingsbury TJ, Cunningham KW, Perez-Riba M, Estivill X, de la Luna S.
Human Molecular Genetics 2000 Jul; 9(11):1681.
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A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.
Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS.
The Journal of Biological Chemistry 2000 Mar; 275(12):8719.
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A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).
Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M.
Genomics 2000 Mar; 64(3):252.
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DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways.
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