Endothelial cell lysate transferred to membrane was incubated with RCAN1 polyclonal antibody (Cat # PAB4386) at a 1 : 500 dilution in 2% BSA in TBST at 4°C overnight . Data courtesy of Dr . Katherine Healey, NWCRF Institute, School of Biological Sciences, University of Wales Bangor .
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq
Down syndrome candidate region 1,Down syndrome critical region gene 1,calcipressin 1,calcium and oxidant-inducible mRNA,modulatory calcineurin-interacting protein 1,myocyte-enriched calcineurin-interacting protein 1,near DSCR proline-rich protein