SPTLC1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The SPTLC1 polyclonal antibody (Cat # PAB4378) is used in Western blot to detect SPTLC1 in mouse liver tissue lysate .
Western Blot (Cell lysate)
The SPTLC1 polyclonal antibody (Cat # PAB4378) is used in Western blot to detect SPTLC1 in HeLa cell lysate .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SPTLC1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human SPTLC1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The SPTLC1 polyclonal antibody (Cat # PAB4378) is used in Western blot to detect SPTLC1 in mouse liver tissue lysate .Western Blot (Cell lysate)
The SPTLC1 polyclonal antibody (Cat # PAB4378) is used in Western blot to detect SPTLC1 in HeLa cell lysate .Enzyme-linked Immunoabsorbent Assay
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Gene Info — SPTLC1
Entrez GeneID
10558Protein Accession#
LCB1_HUMANGene Name
SPTLC1
Gene Alias
HSAN, HSAN1, HSN1, LBC1, LCB1, MGC14645, SPT1, SPTI
Gene Description
serine palmitoyltransferase, long chain base subunit 1
Gene Ontology
HyperlinkGene Summary
Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000022810|OTTHUMP00000022811|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase subunit 1|serine-palmitoyl-CoA transferase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis.
Stachowitz S, Alessandrini F, Abeck D, Ring J, Behrendt H.
The Journal of Investigative Dermatology 2002 Nov; 119(5):1048.
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Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum.
He Y, Appel S, Le W.
Brain Research 2001 Aug; 909(1-2):187.
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Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I.
Dawkins JL, Hulme DJ, Brahmbhatt SB, Auer-Grumbach M, Nicholson GA.
Nature Genetics 2001 Mar; 27(3):309.
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Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis.
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