ZMPSTE24 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The ZMPSTE24 polyclonal antibody (Cat # PAB4318) is used in Western blot to detect ZMPSTE24 in T-47D cell lysate .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ZMPSTE24 polyclonal antibody (Cat # PAB4318) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ZMPSTE24.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ZMPSTE24.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The ZMPSTE24 polyclonal antibody (Cat # PAB4318) is used in Western blot to detect ZMPSTE24 in T-47D cell lysate .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ZMPSTE24 polyclonal antibody (Cat # PAB4318) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . HC = hepatocarcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — ZMPSTE24
Entrez GeneID
10269Protein Accession#
FAC1_HUMANGene Name
ZMPSTE24
Gene Alias
FACE-1, FACE1, FLJ14968, STE24, Ste24p
Gene Description
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq
Other Designations
CAAX prenyl protease|OTTHUMP00000006394|farnesylated-proteins converting enzyme 1|prenyl protein-specific endoprotease 1|zinc metalloproteinase STE24
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Interactome
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Disease
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Publication Reference
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Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.
Freije JM, Blay P, Pendas AM, Cadinanos J, Crespo P, Lopez-Otin C.
Genomics 1999 Jun; 58(3):270.
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Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p.
Kumagai H, Kawamura Y, Yanagisawa K, Komano H.
Biochimica et Biophysica Acta 1999 Feb; 1426(3):468.
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Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing.
Tam A, Nouvet FJ, Fujimura-Kamada K, Slunt H, Sisodia SS, Michaelis S.
The Journal of Cell Biology 1998 Aug; 142(3):635.
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Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.
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