FNTB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FNTB.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human FNTB.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with FNTB polyclonal antibody (Cat # PAB4316) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — FNTB
Entrez GeneID
2342Protein Accession#
PFTB_HUMANGene Name
FNTB
Gene Alias
FPTB, MGC31935
Gene Description
farnesyltransferase, CAAX box, beta
Omim ID
134636Gene Ontology
HyperlinkGene Summary
CAAX box
Other Designations
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Interactome
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Disease
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Publication Reference
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Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, Williams TM, Graham SL, Hartman GD, Oliff AI, Heimbrook DC, Kohl NE.
Cancer Research 2001 Dec; 61(24):8758.
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The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.
Wang T, Danielson PD, Li BY, Shah PC, Kim SD, Donahoe PK.
Science 1996 Feb; 271(5252):1120.
Application:WB-Tr, Monkey, COS cells.
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cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences.
Andres DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U.
Genomics 1993 Oct; 18(1):105.
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Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
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