MGAT2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate (35 ug/lane) with MGAT2 polyclonal antibody (Cat # PAB4307).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MGAT2 polyclonal antibody (Cat # PAB4307) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MGAT2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human MGAT2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate (35 ug/lane) with MGAT2 polyclonal antibody (Cat # PAB4307).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with MGAT2 polyclonal antibody (Cat # PAB4307) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma . -
Gene Info — MGAT2
Entrez GeneID
4247Protein Accession#
GNT2_HUMANGene Name
MGAT2
Gene Alias
CDGS2, GLCNACTII, GNT-II, GNT2
Gene Description
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Gene Ontology
HyperlinkGene Summary
The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq
Other Designations
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase|Beta-1,2-N-acetylglucosaminyltransferase II|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II|UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylgluc
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Interactome
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Pathway
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Publication Reference
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MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
Yen CL, Farese RV Jr.
The Journal of Biological Chemistry 2003 May; 278(20):18532.
Application：WB-Tr, Inset, Sf9 cells.
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Transcriptional regulation of the human UDP-GlcNAc:alpha-6-D-mannoside beta-1-2-N-acetylglucosaminyltransferase II gene (MGAT2) which controls complex N-glycan synthesis.
Chen SH, Zhou S, Tan J, Schachter H.
Glycoconjugate Journal 1998 Mar; 15(3):301.
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Mutations in the MGAT2 gene controlling complex N-glycan synthesis cause carbohydrate-deficient glycoprotein syndrome type II, an autosomal recessive disease with defective brain development.
Tan J, Dunn J, Jaeken J, Schachter H.
American Journal of Human Genetics 1996 Oct; 59(4):810.
Application：WB-Re, N/A, Recombinant protein.
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MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
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