Products

Western Blot (Recombinant protein)

Western blot analysis of ARFGAP1 polyclonal antibody (Cat # PAB4255) against rat recombinant ARFGAP1 (30, 10, and 3 ng/lane, left to right) . ARFGAP1 (arrow) was detected using the purified ARFGAP1 polyclonal antibody (Cat # PAB4255) . Data courtesy of Dr . Dan Cassel, Department of Biology, Technion, Haifa, Israel .

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ARFGAP1 polyclonal antibody (Cat # PAB4255) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .

Enzyme-linked Immunoabsorbent Assay

Entrez GeneID

55738

Protein Accession#

NP_060679;Q8N6T3

Gene Name

ARFGAP1

Gene Alias

ARF1GAP, HRIHFB2281, MGC39924

Gene Description

ADP-ribosylation factor GTPase activating protein 1

Omim ID

608377

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

ADP-ribosylation factor 1 GTPase activating protein|ARF1-directed GTPase-activating protein|GAP protein|OTTHUMP00000031551