LLGL1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of LLGL1 polyclonal antibody (Cat # PAB4246) in 293 cell line lysate . LLGL1 (arrow) was detected using the purified LLGL1 polyclonal antibody (Cat # PAB4246) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LLGL1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human LLGL1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LLGL1 polyclonal antibody (Cat # PAB4246) in 293 cell line lysate . LLGL1 (arrow) was detected using the purified LLGL1 polyclonal antibody (Cat # PAB4246) .Enzyme-linked Immunoabsorbent Assay
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Gene Info — LLGL1
Entrez GeneID
3996Protein Accession#
NP_004131;Q15334Gene Name
LLGL1
Gene Alias
DLG4, HUGL, HUGL-1, HUGL1, LLGL
Gene Description
lethal giant larvae homolog 1 (Drosophila)
Omim ID
600966Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq
Other Designations
lethal giant larvae homolog 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.
Schimanski CC, Schmitz G, Kashyap A, Bosserhoff AK, Bataille F, Schafer SC, Lehr HA, Berger MR, Galle PR, Strand S, Strand D.
Oncogene 2005 Apr; 24(19):3100.
Application：IF, IHC-P, Human, Human colorectal cancer, Human colon mucosa, HT-29, LSI174T, SW480, SW620 cells.
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The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo.
Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D.
Oncogene 2004 Nov; 23(53):8688.
Application：IF, IP, WB-Tr, Insect, Sf9 cells.
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Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico.
Katoh M, Katoh M.
International Journal of Oncology 2004 Mar; 24(3):737.
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Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.
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