HGS polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HGS.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human HGS.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The HGS polyclonal antibody (Cat # PAB4227) is used in Western blot to detect HGS in HL-60 cell lysate .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with HGS polyclonal antibody (Cat # PAB4227) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .Enzyme-linked Immunoabsorbent Assay
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Gene Info — HGS
Entrez GeneID
9146Protein Accession#
NP_004703;O14964Gene Name
HGS
Gene Alias
HRS, ZFYVE8
Gene Description
hepatocyte growth factor-regulated tyrosine kinase substrate
Omim ID
604375Gene Ontology
HyperlinkOther Designations
human growth factor-regulated tyrosine kinase substrate
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Interactome
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Pathway
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Disease
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Publication Reference
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GRIF1 binds Hrs and is a new regulator of endosomal trafficking.
Kirk E, Chin LS, Li L.
Journal of Cell Science 2006 Nov; 119(Pt 22):4689.
Application:IF, Rat, HeLa, PC-12 cells.
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Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1.
Sasaki Y, Sugamura K.
The Journal of Biological Chemistry 2001 Aug; 276(32):29943.
Application:IP-WB, WB-Tr, Human, Mouse, Ba/3-tTA, 293T cells.
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Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.
Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K.
Molecular and Cellular Biology 2000 Dec; 20(24):9346.
Application:IP-WB, WB-Tr, Human, Monkey, 293T, COS-7 cells.
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GRIF1 binds Hrs and is a new regulator of endosomal trafficking.
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