Western blot analysis of USP16 polyclonal antibody (Cat # PAB4203) in mouse liver tissue lysate (35 ug/lane). USP16 (arrow) was detected using the purified USP16 polyclonal antibody (Cat # PAB4203) (1 : 60 dilution)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with USP16 polyclonal antibody (Cat # PAB4203) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma .
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq