PPP3CC polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of PPP3CC polyclonal antibody (Cat # PAB4154) in A-375 cell lysate. PPP3CC (arrow) was detected using the purified polyclonal antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PPP3CC polyclonal antibody (Cat # PAB4154) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPP3CC.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PPP3CC.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of PPP3CC polyclonal antibody (Cat # PAB4154) in A-375 cell lysate. PPP3CC (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PPP3CC polyclonal antibody (Cat # PAB4154) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — PPP3CC
Entrez GeneID
5533Protein Accession#
NP_005596;Q9BSS6Gene Name
PPP3CC
Gene Alias
CALNA3
Gene Description
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
Omim ID
114107Gene Ontology
HyperlinkGene Summary
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM
Other Designations
calcineurin A gamma
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.
Eastwood SL, Burnet PW, Harrison PJ.
Biological Psychiatry 2005 Apr; 57(7):702.
-
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit.
Gerber DJ, Hall D, Miyakawa T, Demars S, Gogos JA, Karayiorgou M, Tonegawa S.
PNAS 2003 Jul; 100(15):8993.
-
Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com