PTP4A3 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant PTP4A3.
Immunogen
Recombinant protein corresponding to full length human PTP4A3.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse heart tissue lysate (35 ug/lane) with PTP4A3 polyclonal antibody (Cat # PAB4119).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTP4A3
Entrez GeneID
11156Protein Accession#
NP_116000Gene Name
PTP4A3
Gene Alias
PRL-3, PRL-R, PRL3
Gene Description
protein tyrosine phosphatase type IVA, member 3
Omim ID
606449Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq
Other Designations
potentially prenylated protein tyrosine phosphatase
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Interactome
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Publication Reference
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High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases.
Kato H, Semba S, Miskad UA, Seo Y, Kasuga M, Yokozaki H.
Clinical Cancer Research 2004 Nov; 10(21):7318.
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Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells.
Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X, Xu Q.
The American Journal of Pathology 2004 Jun; 164(6):2039.
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Structure of human PRL-3, the phosphatase associated with cancer metastasis.
Kim KA, Song JS, Jee J, Sheen MR, Lee C, Lee TG, Ro S, Cho JM, Lee W, Yamazaki T, Jeon YH, Cheong C.
FEBS Letters 2004 May; 565(1-3):181.
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High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: a predictive molecular marker of metachronous liver and lung metastases.
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