PTPN3 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The PTPN3 polyclonal antibody (Cat # PAB4104) is used in Western blot to detect PTPN3 in mouse brain tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PTPN3 polyclonal antibody (Cat # PAB4104) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTPN3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human PTPN3.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The PTPN3 polyclonal antibody (Cat # PAB4104) is used in Western blot to detect PTPN3 in mouse brain tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PTPN3 polyclonal antibody (Cat # PAB4104) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPN3
Entrez GeneID
5774Protein Accession#
P26045Gene Name
PTPN3
Gene Alias
DKFZp686N0569, PTPH1
Gene Description
protein tyrosine phosphatase, non-receptor type 3
Omim ID
176877Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000021885|cytoskeletal-associated protein tyrosine phosphatase|protein tyrosin phosphatase H1|tyrosine phosphatase
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Interactome
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Disease
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Publication Reference
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Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K, Yachi A.
Journal of Gastroenterology 1994 Dec; 29(6):727.
Application：WB-Ce, WB-Ti, Human hepatocellular carcinoma.
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cDNA cloning of new protein tyrosine phosphatases in the human colon.
Y Arimura, Y Hinoda, F Itoh, M Takekawa, M Tsujisaki, M Adachi, K Imai, A Yachi.
Tumour Biology 1992 Jan; 3(3):180.
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Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.
Yang Q, Tonks NK.
PNAS 1991 Jul; 88(14):5949.
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Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
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