PTPRE polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTPRE.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PTPRE.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPRE
Entrez GeneID
5791Protein Accession#
P23469Gene Name
PTPRE
Gene Alias
DKFZp313F1310, FLJ57799, FLJ58245, HPTPE, PTPE, R-PTP-EPSILON
Gene Description
protein tyrosine phosphatase, receptor type, E
Omim ID
600926Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq
Other Designations
OTTHUMP00000020735|OTTHUMP00000020736|protein tyrosine phosphatase epsilon|protein tyrosine phosphatase, receptor type, epsilon polypeptide
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Interactome
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Disease
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Publication Reference
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Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon.
Toledano-Katchalski H, Tiran Z, Sines T, Shani G, Granot-Attas S, den Hertog J, Elson A.
Molecular and Cellular Biology 2003 Aug; 23(15):5460.
Application:WB, Mouse, NIH/3T3 cells.
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Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.
Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J.
The Journal of Biological Chemistry 2002 Dec; 277(49):47263.
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Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform.
Wabakken T, Hauge H, Funderud S, Aasheim HC.
Scandinavian Journal of Immunology 2002 Sep; 56(3):276.
Application:IF, WB-Tr, Human, HEK 293T cells.
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Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon.
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