PTPN1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant PTPN1.
Immunogen
Recombinant protein corresponding to amino acids 1-321 of human PTPN1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis of Ramos cell lysate (35 ug/lane) with PTPN1 polyclonal antibody (Cat # PAB4089).Enzyme-linked Immunoabsorbent Assay
-
Gene Info — PTPN1
Entrez GeneID
5770Protein Accession#
P18031Gene Name
PTPN1
Gene Alias
PTP1B
Gene Description
protein tyrosine phosphatase, non-receptor type 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq
Other Designations
OTTHUMP00000031266|non-receptor tyrosine phosphatase 1|protein tyrosine phosphatase 1B|protein tyrosine phosphatase, placental
-
Interactomes
-
Pathways
-
Diseases
-
Publication Reference
-
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking.
Ragab A, Bodin S, Viala C, Chap H, Payrastre B, Ragab-Thomas J.
The Journal of Biological Chemistry 2003 Oct; 278(42):40923.
Application:IP, WB, Human, Human platelets.
-
Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells.
Boute N, Boubekeur S, Lacasa D, Issad T.
EMBO Reports 2003 Mar; 4(3):313.
Application:WB-Tr, Human, HEK 293 cells.
-
Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor.
Sun JP, Fedorov AA, Lee SY, Guo XL, Shen K, Lawrence DS, Almo SC, Zhang ZY.
The Journal of Biological Chemistry 2003 Apr; 278(14):12406.
-
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com