BAIAP2 polyclonal antibody
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More Files
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Western Blot
The BAIAP2 polyclonal antibody (Cat # PAB4062) is used in Western blot to detect BAIAP2 in mouse brain tissue lysate (Lane 1) and A-375 cell lysate (Lane 2) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with BAIAP2 polyclonal antibody (Cat # PAB4062) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BAIAP2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human BAIAP2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
The BAIAP2 polyclonal antibody (Cat # PAB4062) is used in Western blot to detect BAIAP2 in mouse brain tissue lysate (Lane 1) and A-375 cell lysate (Lane 2) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with BAIAP2 polyclonal antibody (Cat # PAB4062) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BAIAP2
Entrez GeneID
10458Protein Accession#
NP_006331Gene Name
BAIAP2
Gene Alias
BAP2, IRSP53
Gene Description
BAI1-associated protein 2
Omim ID
605475Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms
Other Designations
insulin receptor substrate p53
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Interactome
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Pathway
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Disease
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Publication Reference
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Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2.
Fujiwara T, Mammoto A, Kim Y, Takai Y.
Biochemical and Biophysical Research Communications 2000 May; 271(3):626.
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The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses.
Abbott MA, Wells DG, Fallon JR.
Journal of Neuroscience 1999 Sep; 19(17):7300.
Application：IF, IHC-Fr, WB-Ti, Rat, Rat brains.
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Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate.
Okamura-Oho Y, Miyashita T, Ohmi K, Yamada M.
Human Molecular Genetics 1999 Jun; 8(6):947.
Application：IF, Human, HeLa cells.
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Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2.
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