Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with TRIB3 polyclonal antibody (Cat # PAB4034) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq
neuronal cell death inducible putative kinase,p65-interacting inhibitor of NF-kappaB,tribbles 3