Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with YWHAB polyclonal antibody (Cat # PAB4033) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq
14-3-3 protein beta/alpha,OTTHUMP00000031075,OTTHUMP00000031076,brain protein 14-3-3, beta isoform,protein 1054,protein kinase C inhibitor protein-1