FGF4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FGF4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human FGF4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The FGF4 polyclonal antibody (Cat # PAB4025) is used in Western blot to detect FGF4 in Jurkat cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with FGF4 polyclonal antibody (Cat # PAB4025) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FGF4
Entrez GeneID
2249Protein Accession#
P08620Gene Name
FGF4
Gene Alias
HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF
Gene Description
fibroblast growth factor 4
Omim ID
164980Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq
Other Designations
heparin secretory transforming protein 1|human stomach cancer, transforming factor from FGF-related oncogene|kaposi sarcoma oncogene|oncogene HST|transforming protein KS3
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Interactome
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Pathway
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Publication Reference
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Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia.
Koh KR, Ohta K, Nakamae H, Hino M, Yamane T, Takubo T, Tatsumi N.
Leukemia Research 2002 Oct; 26(10):933.
Application:Added, Recombinant protein.
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Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts.
Sieuwerts AM, Martens JW, Dorssers LC, Klijn JG, Foekens JA.
Thrombosis and Haemostasis 2002 Apr; 87(4):674.
Application:Added, Recombinant protein.
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HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity.
Yamamoto H, Ochiya T, Tamamushi S, Toriyama-Baba H, Takahama Y, Hirai K, Sasaki H, Sakamoto H, Saito I, Iwamoto T, Kakizoe T, Terada M.
Oncogene 2002 Jan; 21(6):899.
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Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia.
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