USP4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of USP4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human USP4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The USP4 polyclonal antibody (Cat # PAB3920) is used in Western blot to detect USP4 in USP4-transfected HeLa cell lysate. Transfection data is kindly provided by Dr. B. Pierrat from the Novartis Institute for Biomedical Research (Basel, Switzerland) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with USP4 polyclonal antibody (Cat # PAB3920) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. -
Gene Info — USP4
Entrez GeneID
7375Protein Accession#
UBP4_HUMANGene Name
USP4
Gene Alias
MGC149848, MGC149849, UNP, Unph
Gene Description
ubiquitin specific peptidase 4 (proto-oncogene)
Omim ID
603486Gene Ontology
HyperlinkOther Designations
deubiquitinating enzyme 4|ubiquitin carboxyl-terminal esterase 4|ubiquitin carboxyl-terminal hydrolase 4|ubiquitin specific protease 4|ubiquitin specific protease 4 (proto-oncogene)|ubiquitin thiolesterase 4|ubiquitin-specific processing protease 4
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Interactome
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Disease
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Publication Reference
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The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines.
Frederick A, Rolfe M, Chiu MI.
Oncogene 1998 Jan; 16(2):153.
Application:WB-Ce, WB-Tr, Human, HeLa, IMR90, MCF-7 cells.
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Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.
D A Gray, J Inazawa, K Gupta, A Wong, R Ueda, T Takahashi.
Oncogene 1995 Jun; 10(11):2179.
Application:WB-Tr, Mouse, NIH/3T3 cells.
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The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines.
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