USP2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of USP2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human USP2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of USP2 polyclonal antibody (Cat # PAB3915) in K-562 cell line lysates (35 ug/lane). USP2 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with USP2 polyclonal antibody (Cat # PAB3915) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. -
Gene Info — USP2
Entrez GeneID
9099Protein Accession#
UBP2_HUMANGene Name
USP2
Gene Alias
UBP41, USP9
Gene Description
ubiquitin specific peptidase 2
Omim ID
604725Gene Ontology
HyperlinkGene Summary
Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM
Other Designations
ubiquitin carboxyl-terminal hydrolase 2 variant 1|ubiquitin carboxyl-terminal hydrolase 2 variant 2|ubiquitin specific protease 12|ubiquitin specific protease 2|ubiquitin specific protease 9
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Interactome
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Disease
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Publication Reference
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Retraction for D. R. Zweitzig, N. Shcherbik, and D. S. Haines: AAA ATPase P97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive P53 turnover.
Zweitzig DR, Shcherbik N, Haines DS.
Mol Biol Cell 2008 Sep; 19(11):5029.
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Retraction for D. R. Zweitzig, N. Shcherbik, and D. S. Haines: AAA ATPase P97 and adaptor UBXD1 suppress MDM2 ubiquitination and degradation and promote constitutive P53 turnover.
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