Formalin-fixed and paraffin-embedded human cancer tissue reacted with USP2 polyclonal antibody (Cat # PAB3915) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM
ubiquitin carboxyl-terminal hydrolase 2 variant 1,ubiquitin carboxyl-terminal hydrolase 2 variant 2,ubiquitin specific protease 12,ubiquitin specific protease 2,ubiquitin specific protease 9