Formalin-fixed and paraffin-embedded human cancer tissue reacted with USP1 polyclonal antibody (Cat # PAB3912) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq
OTTHUMP00000010530,deubiquitinating enzyme 1,ubiquitin carboxyl terminal hydrolase 1,ubiquitin specific processing protease 1,ubiquitin specific protease 1,ubiquitin thiolesterase 1