UBE2G2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of UBE2G2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human UBE2G2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The UBE2G2 polyclonal antibody (Cat # PAB3900) is used in Western blot to detect UBE2G2 in Jurkat cell lysate. -
Gene Info — UBE2G2
Entrez GeneID
7327Protein Accession#
UBCJ_HUMANGene Name
UBE2G2
Gene Alias
UBC7
Gene Description
ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)
Omim ID
603124Gene Ontology
HyperlinkGene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
ubiquitin carrier protein G2|ubiquitin conjugating enzyme 7|ubiquitin conjugating enzyme G2|ubiquitin-conjugating enzyme E2G 2|ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)|ubiquitin-protein ligase G2
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Interactome
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Pathway
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Publication Reference
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Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+.
Webster JM, Tiwari S, Weissman AM, Wojcikiewicz RJ.
The Journal of Biological Chemistry 2003 Oct; 278(40):38238.
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Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene.
Katsanis N, Fisher EM.
Genomics 1998 Jul; 51(1):128.
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Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization.
Rose SA, Leek JP, Moynihan TP, Ardley HC, Markham AF, Robinson PA.
Cytogenetics and Cell Genetics 1998 Jan; 83(1-2):98.
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Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-associated degradation pathway, and is inhibited by chelation of intracellular Zn2+.
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