Western blot analysis of UBE2H (arrow) using UBE2H polyclonal antibody (Cat # PAB3899). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the UBE2H gene (Lane 2).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq
ubiquitin carrier protein H,ubiquitin-conjugating enzyme E2H,ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8),ubiquitin-protein ligase H