Western blot analysis of UBE4A polyclonal antibody (Cat # PAB3891) in NCI-H460 and CEM cell line lysates (35 ug/lane). UBE4A (arrow) was detected using the purified polyclonal antibody (1:1000 dilution).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. [provided by RefSeq
homologous to yeast UFD2,ubiquitin conjugation factor E4 A,ubiquitination factor E4A,ubiquitination factor E4A (homologous to yeast UFD2)