MSTN polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of MSTN polyclonal antibody (Cat # PAB3887) in mouse liver tissue lysate. MSTN (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with MSTN polyclonal antibody (Cat # PAB3887) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MSTN.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 17-46 at N-terminus of human MSTN.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50)
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of MSTN polyclonal antibody (Cat # PAB3887) in mouse liver tissue lysate. MSTN (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with MSTN polyclonal antibody (Cat # PAB3887) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — MSTN
Entrez GeneID
2660Protein Accession#
O14793Gene Name
MSTN
Gene Alias
GDF8
Gene Description
myostatin
Omim ID
601788Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq
Other Designations
growth differentiation factor 8
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Interactome
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Disease
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Publication Reference
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Analysis of meat color, meat tenderness and fatty acid composition of meat in second filial hybrid offspring of MSTN mutant pigs.
Kai Gao, Zhaobo Luo, Shengzhong Han, Zhouyan Li, Hak Myong Choe, Hyo Jin Paek, Biaohu Quan, Jindan Kang, Xijun Yin.
Meat Science 2022 Nov; 193:108929.
Application：WB-Ce, Pig, Pig longissimus thoracis muscle.
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The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.
Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, Wolfman NM, Qiu Y.
The Journal of Biological Chemistry 2002 Oct; 27(43):40735.
Application：IP, WB-Ce, Mouse, Serum.
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Insulin-like growth factor-1 and myostatin mRNA expression in muscle: comparison between 62-77 and 21-31 yr old men.
Welle S, Bhatt K, Shah B, Thornton C.
Experimental Gerontology 2002 Jun; 37(6):833.
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Bone mineral content and density in the humerus of adult myostatin-deficient mice.
Hamrick MW, McPherron AC, Lovejoy CO.
Calcified Tissue International 2002 Jun; 71(1):63.
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Analysis of meat color, meat tenderness and fatty acid composition of meat in second filial hybrid offspring of MSTN mutant pigs.
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