VEGFC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of VEGFC.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human VEGFC.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of VEGFC polyclonal antibody (Cat # PAB3867). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the VEGFC gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with VEGFC polyclonal antibody (Cat # PAB3867) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — VEGFC
Entrez GeneID
7424Protein Accession#
NP_005420;P49767Gene Name
VEGFC
Gene Alias
Flt4-L, VRP
Gene Description
vascular endothelial growth factor C
Omim ID
601528Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq
Other Designations
FLT4 ligand DHM|vascular endothelial growth factor-related protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma.
Byeon JS, Jung HY, Lee YJ, Lee D, Lee GH, Myung SJ, Yang SK, Hong WS, Kim JH, Min YI, Kim JS.
Journal of Gastroenterology and Hepatology 2004 Jun; 19(6):648.
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Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis.
Yan C, Zhu ZG, Yu YY, Ji J, Zhang Y, Ji YB, Yan M, Chen J, Liu BY, Yin HR, Lin YZ.
World Journal of Gastroenterology 2004 Mar; 10(6):783.
Application:IHC-P, Human, Human gastric carcinoma.
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Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma.
Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC, Kuo ML.
Cancer Research 2004 Jan; 64(2):554.
Application:IHC-P, WB, Human, A-549, CL1-0, CL5, H1299, H322, PC14 cells, Human lung adenocarcinoma tissues.
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Clinicopathological significance of vascular endothelial growth factor-C and cyclooxygenase-2 in esophageal squamous cell carcinoma.
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