BMPR1A polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot
The BMPR1A polyclonal antibody (Cat # PAB3835) is used in Western blot to detect BMPR1A in mouse muscle tissue lysate (Lane 1) and Hela cell lysate (Lane 2) .
Flow Cytometry
Flow cytometric analysis of WiDr cells using BMPR1A polyclonal antibody (Cat # PAB3835)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMPR1A.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BMPR1A.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Flow Cytometry (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
The BMPR1A polyclonal antibody (Cat # PAB3835) is used in Western blot to detect BMPR1A in mouse muscle tissue lysate (Lane 1) and Hela cell lysate (Lane 2) .Flow Cytometry
Flow cytometric analysis of WiDr cells using BMPR1A polyclonal antibody (Cat # PAB3835)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Gene Info — BMPR1A
Entrez GeneID
657Protein Accession#
NP_004320;P36894Gene Name
BMPR1A
Gene Alias
10q23del, ACVRLK3, ALK3, CD292
Gene Description
bone morphogenetic protein receptor, type IA
Gene Ontology
HyperlinkGene Summary
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq
Other Designations
OTTHUMP00000020014|activin A receptor, type II-like kinase 3
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
Waite KA, Eng C.
Human Molecular Genetics 2003 Mar; 12(6):679.
-
Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes.
Zhou XP, Woodford-Richens K, Lehtonen R, Kurose K, Aldred M, Hampel H, Launonen V, Virta S, Pilarski R, Salovaara R, Bodmer WF, Conrad BA, Dunlop M, Hodgson SV, Iwama T, Jarvinen H, Kellokumpu I, Kim JC, Leggett B, Markie D, Mecklin JP, Neale K, Phillips R, Piris J, Rozen P, Houlston RS, Aaltonen LA, Tomlinson IP, Eng C.
American Journal of Human Genetics 2001 Aug; 69(4):704.
-
Chromosomal localization of three human genes encoding bone morphogenetic protein receptors.
A K Astrom, D Jin, T Imamura, E Roijer, B Rosenzweig, K Miyazono, P ten Dijke, G Stenman.
Mammalian Genome 1999 Mar; 10(3):299.
-
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com