C19orf2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The C19orf2 polyclonal antibody (Cat # PAB3789) is used in Western blot to detect RMP in T-47D (left) and Jurkat (right) cell line lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of C19orf2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human C19orf2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The C19orf2 polyclonal antibody (Cat # PAB3789) is used in Western blot to detect RMP in T-47D (left) and Jurkat (right) cell line lysates. -
Gene Info — C19orf2
Entrez GeneID
8725Protein Accession#
NP_604431;O94763Gene Name
C19orf2
Gene Alias
FLJ10575, NNX3, RMP, URI
Gene Description
chromosome 19 open reading frame 2
Omim ID
603494Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
RNA polymerase II, subunit 5-mediating protein|RPB5-mediating protein|unconventional prefoldin RPB5 interactor
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Interactome
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Disease
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Publication Reference
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Subcellular localization of RPB5-mediating protein and its putative functional partner.
Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S.
Molecular and Cellular Biochemistry 2004 Oct; 24(19):8556.
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Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.
Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W.
Science 2003 Nov; 302(5648):1208.
Application：WB, Human, HEK 293 cells.
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Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease.
Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J.
Genomics 1998 Dec; 54(3):511.
Application：IF, IP, Monkey, COS-1 cells.
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Subcellular localization of RPB5-mediating protein and its putative functional partner.
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