TCEB3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NIH/3T3 cell lysate (35 ug/lane) with TCEB3 polyclonal antibody (Cat # PAB3716).
Western Blot (Transfected lysate)
Western blot analysis of TCEB3 (arrow) using TCEB3 polyclonal antibody (Cat # PAB3716).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TCEB3 gene (Lane 2).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TCEB3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human TCEB3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NIH/3T3 cell lysate (35 ug/lane) with TCEB3 polyclonal antibody (Cat # PAB3716).Western Blot (Transfected lysate)
Western blot analysis of TCEB3 (arrow) using TCEB3 polyclonal antibody (Cat # PAB3716).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the TCEB3 gene (Lane 2). -
Gene Info — TCEB3
Entrez GeneID
6924Protein Accession#
NP_003189;Q14241Gene Name
TCEB3
Gene Alias
FLJ38760, FLJ42849, SIII, TCEB3A
Gene Description
transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
Omim ID
600786Gene Ontology
HyperlinkGene Summary
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq
Other Designations
OTTHUMP00000002990|elongin A|transcription elongation factor B (SIII), polypeptide 3 (110kD)|transcription elongation factor B alpha subunit
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Interactome
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Disease
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Publication Reference
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP.
PNAS 2004 Aug; 101(33):12130.
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Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.
Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T.
Biochemical and Biophysical Research Communications 2003 Sep; 309(1):189.
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The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
Trends in Biochemical Sciences 2002 May; 27(5):235.
Application：IHC, WB-Tr, Human, Mammalian cells.
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
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