DDX58 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of 293 cell lysate (35 ug/lane) with DDX58 polyclonal antibody (Cat # PAB3686).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DDX58.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human DDX58.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of 293 cell lysate (35 ug/lane) with DDX58 polyclonal antibody (Cat # PAB3686). -
Gene Info — DDX58
Entrez GeneID
23586Protein Accession#
NP_055129;O95786Gene Name
DDX58
Gene Alias
DKFZp434J1111, DKFZp686N19181, FLJ13599, RIG-I
Gene Description
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Omim ID
609631Gene Ontology
HyperlinkGene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq
Other Designations
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I|OTTHUMP00000021185|OTTHUMP00000045225|RNA helicase RIG-I|retinoic acid-inducible gene I
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Interactome
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Disease
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Publication Reference
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Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
Breiman A, Grandvaux N, Lin R, Ottone C, Akira S, Yoneyama M, Fujita T, Hiscott J, Meurs EF.
Journal of Virology 2005 Apr; 79(7):3969.
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Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
Li K, Chen Z, Kato N, Gale M Jr, Lemon SM.
The Journal of Biological Chemistry 2005 Apr; 280(17):16739.
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Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells.
Cui XF, Imaizumi T, Yoshida H, Borden EC, Satoh K.
Biochemistry and Cell Biology 2004 Jun; 82(3):401.
Application：WB, Human, Human lymphoid cells, MCF-7 cells.
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Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
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