BMP7 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMP7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BMP7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:50-100)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of BMP7 polyclonal antibody (Cat # PAB3676). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Bmp7 gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with BMP7 polyclonal antibody (Cat # PAB3676) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.Immunofluorescence
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Gene Info — BMP7
Entrez GeneID
655Protein Accession#
BMHU7Gene Name
BMP7
Gene Alias
OP-1
Gene Description
bone morphogenetic protein 7
Omim ID
112267Gene Ontology
HyperlinkGene Summary
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq
Other Designations
OTTHUMP00000031357|osteogenic protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Alterations in endogenous osteogenic protein-1 with degeneration of human articular cartilage.
Merrihew C, Kumar B, Heretis K, Rueger DC, Kuettner KE, Chubinskaya S.
Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society 2003 Sep; 21(5):899.
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Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats.
Maric I, Poljak L, Zoricic S, Bobinac D, Bosukonda D, Sampath KT, Vukicevic S.
Journal of Cellular Physiology 2003 Aug; 196(2):258.
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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
Greenwald J, Groppe J, Gray P, Wiater E, Kwiatkowski W, Vale W, Choe S.
Molecular Cell 2003 Mar; 11(3):605.
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Alterations in endogenous osteogenic protein-1 with degeneration of human articular cartilage.
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