BMP6 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The BMP6 polyclonal antibody (Cat # PAB3675) is used in Western blot to detect BMP6 in HL-60 cell lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMP6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BMP6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The BMP6 polyclonal antibody (Cat # PAB3675) is used in Western blot to detect BMP6 in HL-60 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — BMP6
Entrez GeneID
654Protein Accession#
BMHU6Gene Name
BMP6
Gene Alias
VGR, VGR1
Gene Description
bone morphogenetic protein 6
Omim ID
112266Gene Ontology
HyperlinkGene Summary
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq
Other Designations
OTTHUMP00000016006|Vg1-related sequence|vegetal related growth factor (TGFB-related)|vegetal-related (TGFB related) cytokine
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Interactome
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Pathway
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Disease
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Publication Reference
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Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis.
Lories RJ, Derese I, Ceuppens JL, Luyten FP.
Arthritis and Rheumatism 2003 Oct; 48(10):2807.
Application：IHC, WB-Ti, Human, Synovial.
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Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro.
Bobacz K, Gruber R, Soleiman A, Erlacher L, Smolen JS, Graninger WB.
Arthritis and Rheumatism 2003 Sep; 48(9):2501.
Application：WB, Human, Human chondrocytes.
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Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6).
Tamada H, Kitazawa R, Gohji K, Kamidono S, Maeda S, Kitazawa S.
Biochimica et Biophysica Acta 1998 Feb; 1395(3):247.
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Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis.
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