Western blot analysis of MDA-MB-435 cell lysate (35 ug/lane) with BMP4 polyclonal antibody (Cat # PAB3673).
Western Blot (Transfected lysate)
Western blot analysis of BMP4 (arrow) using BMP4 polyclonal antibody (Cat # PAB3673). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the BMP4 gene (Lane 2).
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with BMP4 polyclonal antibody (Cat # PAB3673) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq