BMP4 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMP4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human BMP4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-435 cell lysate (35 ug/lane) with BMP4 polyclonal antibody (Cat # PAB3673).Western Blot (Transfected lysate)
Western blot analysis of BMP4 (arrow) using BMP4 polyclonal antibody (Cat # PAB3673).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the BMP4 gene (Lane 2).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with BMP4 polyclonal antibody (Cat # PAB3673) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. -
Gene Info — BMP4
Entrez GeneID
652Protein Accession#
NP_001193Gene Name
BMP4
Gene Alias
BMP2B, BMP2B1, MCOPS6, ZYME
Gene Description
bone morphogenetic protein 4
Omim ID
112262Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq
Other Designations
bone morphogenetic protein 2B
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Interactome
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Pathway
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Disease
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Publication Reference
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A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs.
Kathryn M Meurs, Keith Montgomery, Steven G Friedenberg, Brian Williams, Brian C Gilger.
BMC Veterinary Research 2021 Jul; 17(1):254.
Application:IHC-P, Dog, Dog corneal specimens.
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Identification of a putative autocrine bone morphogenetic protein-signaling pathway in human ovarian surface epithelium and ovarian cancer cells.
Shepherd TG, Nachtigal MW.
Endocrinology 2003 Aug; 144(8):3306.
Application:IP, WB, Human, CaOV3, HeyC2, OC28, OC30, OC 31, SkOV3 cells.
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Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress stimulates an inflammatory response.
Sorescu GP, Sykes M, Weiss D, Platt MO, Saha A, Hwang J, Boyd N, Boo YC, Vega JD, Taylor WR, Jo H.
The Journal of Biological Chemistry 2003 May; 278(33):31128.
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Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells.
Chadwick K, Wang L, Li L, Menendez P, Murdoch B, Rouleau A, Bhatia M.
Blood 2003 Aug; 102(3):906.
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A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs.
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