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Last updated: 2016/12/4
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GRM8 polyclonal antibody

  • Catalog # : PAB3655
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of GRM8.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GRM8.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Protein G purification
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • The GRM8 polyclonal antibody (Cat # PAB3655) is used in Western blot to detect GRM8 in mouse brain tissue lysate.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2918
  • Protein Accession#:
  • NP_000836;O00222
  • Gene Name:
  • GRM8
  • Gene Alias:
  • FLJ41058,GLUR8,GPRC1H,MGC126724,MGLUR8,mGlu8
  • Gene Description:
  • glutamate receptor, metabotropic 8
  • Gene Summary:
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000024506,glutamate metabotropic receptor 8
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