GRM8 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRM8.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GRM8.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
The GRM8 polyclonal antibody (Cat # PAB3655) is used in Western blot to detect GRM8 in mouse brain tissue lysate. -
Gene Info — GRM8
Entrez GeneID
2918Protein Accession#
NP_000836;O00222Gene Name
GRM8
Gene Alias
FLJ41058, GLUR8, GPRC1H, MGC126724, MGLUR8, mGlu8
Gene Description
glutamate receptor, metabotropic 8
Omim ID
601116Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000024506|glutamate metabotropic receptor 8
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.
Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RL, Mutel V.
Brain Research. Molecular Brain Research 1999 Apr; 67(2):201.
-
Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.
Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR Jr, Johnson BG, Schoepp DD, Belagaje RM.
Brain Research. Molecular Brain Research 1998 Jan; 53(1-2):88.
-
The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1.
Scherer SW, Soder S, Duvoisin RM, Huizenga JJ, Tsui LC.
Genomics 1997 Sep; 44(2):232.
-
Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com