SIGLEC5 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SIGLEC5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SIGLEC5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The SIGLEC5 polyclonal antibody (Cat # PAB3635) is used in Western blot to detect SIGLEC5 in mouse liver tissue lysate. -
Gene Info — SIGLEC5
Entrez GeneID
8778Protein Accession#
AAD50978Gene Name
SIGLEC5
Gene Alias
CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5
Gene Description
sialic acid binding Ig-like lectin 5
Omim ID
604200Gene Ontology
HyperlinkGene Summary
The sialic acid-binding immunoglobulin-like lectins (SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin (Ig) superfamily that mediate protein-carbohydrate interactions. They specifically interact with sialic acids in glycoproteins and glycolipids, with each SIGLEC having a particular preference for both the nature of the sialic acid and its glycosidic linkage to adjacent sugars. SIGLECs have similar structures, including extracellular Ig-like domains composed of an N-terminal V-set domain followed by varying numbers of C2-set domains. It appears that all SIGLECs have an unusual arrangement of conserved cysteine residues in the V-set and adjacent C2-set domains. Most SIGLECs are expressed uniquely within the hematopoietic system (Cornish et al., 1998 [PubMed 9731071]).[supplied by OMIM
Other Designations
CD33 antigen-like 2|OB binding protein-2|sialic acid-binding immunoglobulin-like lectin 5
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Interactome
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Publication Reference
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Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes.
Erickson-Miller CL, Freeman SD, Hopson CB, D'Alessio KJ, Fischer EI, Kikly KK, Abrahamson JA, Holmes SD, King AG.
Experimental Hematology 2003 May; 31(5):382.
Application:Flow Cyt, Func, Human, Blood, Cell lines, Marrow, Monocytes, Neurophils, Phagocytes.
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OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.
Patel N, Brinkman-Van der Linden EC, Altmann SW, Gish K, Balasubramanian S, Timans JC, Peterson D, Bell MP, Bazan JF, Varki A, Kastelein RA.
The Journal of Biological Chemistry 1999 Aug; 274(32):22729.
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Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33.
Cornish AL, Freeman S, Forbes G, Ni J, Zhang M, Cepeda M, Gentz R, Augustus M, Carter KC, Crocker PR.
Blood 1998 Sep; 92(6):2123.
Application:Flow Cyt, WB-Ce, Human, Monkey, COS-1, HL-60, K-562, KG, KG1A, THP-1, U937 cells, Lymphocytes, Monocytes, Neutrophils.
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Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes.
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