Products

Western Blot (Transfected lysate)

Western blot analysis of GJB6 (arrow) using GJB6 polyclonal antibody (Cat # PAB3591).
293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GJB6 gene (Lane 2).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with GJB6 polyclonal antibody (Cat # PAB3591) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human prostate carcinomareacted with GJB6 polyclonal antibody (Cat # PAB3591), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Entrez GeneID

10804

Protein Accession#

O95452

Gene Name

GJB6

Gene Alias

CX30, DFNA3, ED2, EDH, HED

Gene Description

gap junction protein, beta 6, 30kDa

Omim ID

129500 601544 604418

Gene Ontology

Hyperlink

Gene Summary

Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq

Other Designations

OTTHUMP00000018096|OTTHUMP00000176870|OTTHUMP00000176871|OTTHUMP00000176872|connexin 30|ectodermal dysplasia 2, hidrotic (Clouston syndrome)|gap junction protein, beta 6|gap junction protein, beta 6 (connexin 30)