STAT2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of K-562 cell lysate (35 ug/lane) with STAT2 polyclonal antibody (Cat # PAB3578).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with STAT2 polyclonal antibody (Cat # PAB3578) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STAT2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human STAT2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of K-562 cell lysate (35 ug/lane) with STAT2 polyclonal antibody (Cat # PAB3578).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with STAT2 polyclonal antibody (Cat # PAB3578) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — STAT2
Entrez GeneID
6773Protein Accession#
P52630Gene Name
STAT2
Gene Alias
ISGF-3, MGC59816, P113, STAT113
Gene Description
signal transducer and activator of transcription 2, 113kDa
Omim ID
600556Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. [provided by RefSeq
Other Designations
interferon alpha induced transcriptional activator|signal transducer and activator of transcription 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation.
Rodriguez JJ, Wang LF, Horvath CM.
Journal of Virology 2003 Nov; 77(21):11842.
Application：IF, WB-Tr, Human, 2fTGH, HEK 293T cells.
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The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling.
Gotoh B, Takeuchi K, Komatsu T, Yokoo J.
Journal of Virology 2003 Mar; 77(6):3360.
Application：WB, Human, HeLa, U3A cells.
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Affinity of Stat2 for the subunits of the interferon alpha receptor.
Saleh AZ, Nguyen VP, Krolewski JJ.
Biochemistry 2002 Sep; 41(37):11261.
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Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation.
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