TGM2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of TGM2 polyclonal antibody (Cat # PAB3508) in K-562 cell line lysates (35 ug/lane). TGM2 (arrow) was detected using the purified polyclonal antibody (1:1000 dilution).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TGM2 polyclonal antibody (Cat # PAB3508) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TGM2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human TGM2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Immunofluorescence (1:10-50)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TGM2 polyclonal antibody (Cat # PAB3508) in K-562 cell line lysates (35 ug/lane). TGM2 (arrow) was detected using the purified polyclonal antibody (1:1000 dilution).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TGM2 polyclonal antibody (Cat # PAB3508) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.Immunofluorescence
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Gene Info — TGM2
Entrez GeneID
7052Protein Accession#
NP_004604;P21980Gene Name
TGM2
Gene Alias
G-ALPHA-h, GNAH, TG2, TGC
Gene Description
transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Omim ID
190196Gene Ontology
HyperlinkGene Summary
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
C polypeptide|OTTHUMP00000030960|TGase C|TGase-H|protein-glutamine-gamma-glutamyltransferase|tissue transglutaminase|transglutaminase 2|transglutaminase C
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Interactome
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Disease
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Publication Reference
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Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online.
Porzio O, Massa O, Cunsolo V, Colombo C, Malaponti M, Bertuzzi F, Hansen T, Johansen A, Pedersen O, Meschi F, Terrinoni A, Melino G, Federici M, Decarlo N, Menicagli M, Campani D, Marchetti P, Ferdaoussi M, Froguel P, Federici G, Vaxillaire M, Barbetti F.
Human Mutation 2007 Nov; 28(11):1150.
Application：IF, IHC, WB-Ce, Human, Human normal pancreases, human pancreatic islets, fibroblasts.
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Transglutaminases: the missing link in nephrogenic systemic fibrosis.
Parsons AC, Yosipovitch G, Sheehan DJ, Sangueza OP, Greenberg CS, Sane DC.
The American Journal of Dermatopathology 2007 Oct; 29(5):433.
Application：IHC-P, Human, Human skin biopsies.
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Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online.
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