Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with TGFBR1 polyclonal antibody (Cat # PAB3503) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
OTTHUMP00000021783,activin A receptor type II-like kinase, 53kD,activin A receptor type II-like kinase, 53kDa,activin receptor-like kinase 5,serine/threonine-protein kinase receptor R4,transforming growth factor beta receptor I,transforming growth factor,